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Hemophagocytic lymphohistiocytosis (HLH) is a life threatening inflammatory emergency resulting from dysregulation of the immune system.
HLH is often mistaken as culture-negative sepsis, and can be difficult to distinguish from critical care patients with MODS from other causes. It is essential to conduct a rapid evaluation for an underlying condition since it will impact on the choice and order of therapies
Most Recent References
Hemophagocytic Syndrome and Critical Illness: New Insights into Diagnosis and Management. Tothova Z, Berliner N. J Intensive Care Med. 2014 Jan 8.
Hemophagocytic lymphohistiocytosis in a patient with CD3δ deficiency. Alsalamah M, Sarpal A, Siu VM, Gibson P, Rypar CA, Barton M, Salvadori AI, Goobie S. LymphoSign Journal. 2015; 2:201–206
Hemophagocytic lymphohistiocytosis and primary immune deficiency disorders. Faitelson Y, Grunebaum E. Clin Immunol. 2014 Nov;155(1):118-25
