Intrapleural Alteplase (TPA) Administration for Empyema / Parapneumonic Effusion

Last Updated: September 5th, 2023
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Overview

This document and the linked documents cover the management of complicated pneumonia, specifically outlining the Intrapleural Alteplase (Tissue Plasminogen Activator, aka TPA) administration for when treating Empyema / Parapneumonic Effusion. Since the Covid pandemic we have seen an increase in severe complicated necrotizing bacterial pneumonia due to Group A Streptococcus pyogenes (Group A) and Streptococcus pneumoniae.

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