Tranexamic Acid in Pediatric Trauma

Authors: Simon J Parsons

Tags: Anesthesia, Brain, Critical Care, Emergency Medicine, Physicians, Surgery

Last Updated: June 8th, 2020

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This document summarizes our recommended use of tranexamic acid in children with severe trauma, including intra-abdominal blunt trauma and traumatic brain injury.

Most Recent References

Effects of tranexamic acid on death, disability, vascular occlusive events and other morbidities in patients with acute traumatic brain injury (CRASH-3): a randomised, placebo-controlled trial. CRASH-3 trial collaborators. Lancet. 2019 Nov 9;394(10210):1713-1723.
Safety of Tranexamic Acid During Pediatric Trauma: A Nationwide Database Study. Maeda T, Michihata N, Sasabuchi Y, Matsui H, Ohnishi Y, Miyata S, Yasunaga H. Pediatr Crit Care Med. 2018 Sep 7
Intraoperative tranexamic acid is associated with postoperative stroke in patients undergoing cardiac surgery. Zhou ZF, Zhang FJ, Huo YF, Yu YX, Yu LN, Sun K, Sun LH, Xing XF, Yan M. PLoS One. 2017 May 26;12(5):e0177011. doi: 10.1371/journal.pone.0177011. eCollection 2017.

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Tranexamic Acid in Pediatric Trauma

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Pediatric Clinical Care Guidelines is a collaborative, not-for-profit ACH initiative. The site is shared widely with medical professionals in order to disseminate best practices and encourage dialogue around protocols and procedures.