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Tumor lysis syndrome (TLS) is a potentially fatal complication of certain malignancies that may rarely occur spontaneously, but most often occurs at the initiation of chemotherapy. Deciding which child is at highest risk and when to initiate CRRT can be problematic. This document outlines TLS risk prediction and the key criteria to consider when considering CRRT.
Most Recent References
Tumor lysis syndrome. Williams SM, Killeen AA. Arch Pathol Lab Med 2019;143:386-93.
Tumour lysis syndrome in children with haematological cancers: experience at a tertiary care hospital in Karachi. Saeed F, Vadsaria K, Siddiqui DF et al. J Pak Med Assoc 2018;68:1625-30.
The optimal single-dose regimen of rasburicase for management of tumor lysis syndrome in children and adults: a systematic review and meta-analysis. Yu X, Liu L, Nie X et al. J Clin Pharm Ther 2017;42(1):18-26.
