Vancomycin Guideline

Authors: Jaime Blackwood, Timothy Kraft

Tags: Blood, Bone, Brain, Critical Care, Drug Dosing, Heart, Infectious Diseases, Intestine, Kidneys, Lung, Nursing, Pediatric Hospital Medicine, Physicians, Skin

Last Updated: January 31st, 2024

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This guideline provides overview on vancomycin use, dosing and drug therapeutic monitoring. Drug therapeutic monitoring provides information when to do levels, therapeutic targets for different infections, when to hold and when not to hold vancomycin dose. Also, gives nursing guidance on monitoring and administration of vancomycin in patients with AKI.

Most Recent References

Mechanisms of antimicrobial-induced nephrotoxicity in children. Downes, K. J., Hayes, M., Fitzgerald, J. C., Pais, G. M., Liu, J., Zane, N. R. … & Zuppa, A. F. (2020). Journal of Antimicrobial Chemotherapy, 75(1), 1-13.
Acute kidney injury in patients treated with vancomycin and piperacillin-tazobactam: A retrospective cohort analysis. Rutter WC et al. J Hosp Med 2017 Feb; 12:77.
Frequency of and risk factors for acute kidney injury associated with vancomycin use in the pediatric intensive care unit. Bonazza, S., Bresee, L. C., Kraft, T., Ross, B. C., & Dersch-Mills, D. (2016). The Journal of Pediatric Pharmacology and Therapeutics, 21(6), 486-493

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Vancomycin Guideline

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Pediatric Clinical Care Guidelines is a collaborative, not-for-profit ACH initiative. The site is shared widely with medical professionals in order to disseminate best practices and encourage dialogue around protocols and procedures.